The syntheses and A1 adenosine receptor affinities of a number of imidazo [1, 2-a] quinoxalin-4-amines are reported. Structure—activity relationships within the series and in comparison with other similar tricyclic nonxanthine adenosine antagonists are discussed, leading to a putative common binding mode of these nitrogen-containing heterocycles to A1 adenosine receptors. Secondary amino compounds displayed the best affinities toward ...
![4-chloroimidazo[1,2-a]quinoxaline Structure](https://image.chemsrc.com/caspic/478/191349-69-6.png)
