A aeries of phenylethylamines related to methoxamine has been prepared and evaluated for direct al-receptor agonist activity. It has been observed that for open-chain compounds such as methoxamine, in which the amine-containing portion is free to adopt numerous conformations, an hydroxyl group is necessary for direct al-adrenergic activity. When the hydroxyl is removed, however, the direct component. of activity is greatly reduced unless ...
![3,6-dimethoxy-1,8,9,10-tetrahydrotricyclo[6.2.2.02,7]dodeca-3,9-diene结构式](https://image.chemsrc.com/caspic/216/17547-70-5.png)
