. alpha.-Adrenergic agents. 1. Direct-acting. alpha. 1 agonists related to methoxamine

RM DeMarinis, WM Bryan, DH Shah…

Index: DeMarinis, R. M.; Bryan, W. M.; Shah, D. H.; Hieble, J. P.; Pendleton, R. G. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1432 - 1437

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Citation Number: 43

Abstract

A aeries of phenylethylamines related to methoxamine has been prepared and evaluated for direct al-receptor agonist activity. It has been observed that for open-chain compounds such as methoxamine, in which the amine-containing portion is free to adopt numerous conformations, an hydroxyl group is necessary for direct al-adrenergic activity. When the hydroxyl is removed, however, the direct component. of activity is greatly reduced unless ...