A novel orally active inhibitor of HLE

…, Z Kapui, S Bátori, LT Nagy, L Vasvári-Debreczy…

文献索引：Varga, Marton; Kapui, Zoltan; Batori, Sandor; Nagy, Lajos T.; Vasvari-Debreczy, Lelle; Mikus, Endre; Urban-Szabo, Katalin; Aranyi, Peter European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 421 - 425

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被引用次数: 17

摘要

Human leukocyte elastase (HLE) is a serine proteinase, capable of degrading a variety of structural matrix proteins. SSR69071 2-[(4-isopropyl-6-methoxy-1, 1-dioxido-3-oxo-1, 2- benzisothiazol-2 (3H)-yl) methoxy]-9-(2-piperidin-1-ylethoxy)-4H-pyrido [1, 2-a] pyrimidin-4- one was selected as a novel orally active HLE inhibitor for treatment of chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis and several inflammatory ...