Human leukocyte elastase (HLE) is a serine proteinase, capable of degrading a variety of structural matrix proteins. SSR69071 2-[(4-isopropyl-6-methoxy-1, 1-dioxido-3-oxo-1, 2- benzisothiazol-2 (3H)-yl) methoxy]-9-(2-piperidin-1-ylethoxy)-4H-pyrido [1, 2-a] pyrimidin-4- one was selected as a novel orally active HLE inhibitor for treatment of chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis and several inflammatory ...
