Novel Dithiocarbamic Acid Esters Derived from 6??Aminomethyl??4??anilinoquinazolines and 6??Aminomethyl??4??anilino??3??cyanoquinolines as Potent EGFR Inhibitors
Abstract Two series of dithiocarbamic acid esters, 4-anilinoquinazoline-6- ylmethylcarbamodithioic acid esters and 3-cyano-4-anilinoquinolin-6- ylmethylcarbamodithioic acid esters, were designed and synthesized. The effect of the synthesized compounds on cell proliferation was evaluated by MTT assay against three human cancer cell lines: MDA-MB-468, SK-BR-3 and HCT-116. Most of the compounds ...
