Novel Dithiocarbamic Acid Esters Derived from 6??Aminomethyl??4??anilinoquinazolines and 6??Aminomethyl??4??anilino??3??cyanoquinolines as Potent EGFR Inhibitors

…, R Li, K Qiao, Z Ge, L Zhang, T Cheng…

Index: Zhang, Xin; Li, Ridong; Qiao, Kang; Ge, Zemei; Zhang, Liangren; Cheng, Tieming; Li, Runtao Archiv der Pharmazie, 2013 , vol. 346, # 1 p. 44 - 52

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Citation Number: 6

Abstract

Abstract Two series of dithiocarbamic acid esters, 4-anilinoquinazoline-6- ylmethylcarbamodithioic acid esters and 3-cyano-4-anilinoquinolin-6- ylmethylcarbamodithioic acid esters, were designed and synthesized. The effect of the synthesized compounds on cell proliferation was evaluated by MTT assay against three human cancer cell lines: MDA-MB-468, SK-BR-3 and HCT-116. Most of the compounds ...