Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl) adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive …

…, T Murayama, Y Nomura, A Matsuda

文献索引：Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890

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被引用次数: 65

摘要

adenosines have (L pdaiad A2 adezuwiae reaptor selectivity in rat brain.” Frorn studies of the & “-activity relationships, an acetylenic functional group at the C-2 position of adenosine was essential for having affinities to both receptors, and the length of the alkyl side chain attached to the ethynyl group influenced either binding affinity or receptor selectivity. Of a series of 2-alkynyladenosines, 2-(l-hexyn-l-yl) adenosine (7) shed the most potent A, ...