Synthesis, Biological Evaluation and In Silico Study of β-Chloro Vinyl Chalcones as Inhibitors of the TNF-α, IL-6 With Anticancer and Antioxidant Activity

BP Bandgar, BS Hote, SH Nile

文献索引：Bandgar, Babasaheb P.; Hote, Baliram S.; Nile, Shivraj H. Letters in Drug Design and Discovery, 2011 , vol. 8, # 8 p. 725 - 732

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摘要

A series of novel β-chloro vinyl chalcones have been synthesized from substituted (Z)-3- chloro-3-phenylacraldehydes with 1-(3-bromo-2-hydroxyl-4, 6-dimethoxyphenyl) ethanone by Claisen-Schmidt condensation reaction. Compounds were screened for anti- inflammatory, anticancer and antioxidant activity. Compounds 6a, 6d and 6f revealed promising anti-inflammatory activity (87-99%) with less cytotoxicity (4-9%) at 10 µ M. ...