Abstract A new synthesis of isothiazoles is reported which involves the reaction of Vilsmeier salts of N, N-dimethylamides with enamino nitriles, and treatment of the intermediates successively with sodium hydrosulfide and iodine. 4-Isothiazolecarbonitriles prepared were: 3-phenyl; 3, 5-dimethyl; 3, 5-diphenyl; 3-methyl-5-phenyl; and 3-phenyl-5-methyl. The 5- phenylisothiazoles were obtained in low yields due to a side reaction involving the ...
