Synthesis, Characterization and Pharmacological Evaluation of N-Substituted Derivatives of 5-(4-Nitrophenyl)-1, 3, 4-oxadiazole-2yl-2"-sulphanyl Acetamide

…, K Nafeesa, A Malik, M Ashraf, T Ismail…

文献索引：Gul, Samreen; Ur-Rehman, Aziz; Abbasi, Muhammad Athar; Nafeesa, Khadija; Malik, Abdul; Ashraf, Muhammad; Ismail, Tayaba; Ahmad, Irshad Asian Journal of Chemistry, 2013 , vol. 25, # 11 p. 6231 - 6236

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被引用次数: 3

摘要

Abstract A series of new N-substituted 5-(4-nitrophenyl)-1, 3, 4-oxadiazole-2-yl-2"-sulphanyl acetamides was synthesized and enzyme inhibiting activity was screened for all these chemical entities. Structural characterization of all these compounds was made by IR, EI-MS and 1H NMR. All derivatives demonstrated different extent of activity for lipoxygenase (LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Compounds 6j exhibited ...