Synthesis of some novel 3, 5-disubstituted 1, 3, 4-oxadiazole derivatives and anticancer activity on EAC animal model

S Dash, BA Kumar, J Singh, BC Maiti…

文献索引：Dash, Sasmita; Kumar, B. Ashok; Singh, Jagadish; Maiti; Maity Medicinal Chemistry Research, 2011 , vol. 20, # 8 p. 1206 - 1213

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被引用次数: 16

摘要

Abstract A series of novel 3, 5-disubstituted 1, 3, 4-oxadiazole-2-thione derivatives (1e, 2e, 3e, 4e, and 5e) have been synthesized from different substituted aromatic acids. The structure determination of these compounds have been made on the basis of IR, 1 H NMR, and Elemental analysis. The effect of all the compounds on tumor growth inhibition was evaluated by studying the parameters—tumor volume, percentage of the tumor cell count ( ...