Tetrahedron letters

Total synthesis of manoalide

ME Garst, EA Tallman, JN Bonfiglio, D Harcourt…

文献索引：Garst; Tallman; Bonfiglio; et al. Tetrahedron Letters, 1986 , vol. 27, # 38 p. 4533 - 4536

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被引用次数: 31

摘要

Analysis of the structure of manoalide led to the following synthetic strategy. We felt that the sensitive hydroxybutenolide moiety could be constructed from a furan. This synthon for the butenolide should be stable during the course of the synthesis, could be unmasked under selective conditions, and would act as a building block for the pyran ring. The six-membered ring could be assembled by the use of Diels-Alder methods recently developed by ...