α-Glucosidase inhibitory antihyperglycemic activity of substituted chromenone derivatives

…, SB Agawane, G Saidachary, K Madhusudana

文献索引：Raju, B. China; Tiwari, Ashok K.; Kumar, J. Ashok; Ali, A. Zehra; Agawane, Sachin B.; Saidachary; Madhusudana Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 358 - 365

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被引用次数: 71

摘要

Series of 3, 4-and 3, 6-disubstituted chromenones including new chromenone derivatives were synthesized applying various synthetic strategies including Pechmann condensation, Knoevenagel condensation, Reimer–Tiemann reaction and Suzuki coupling in very good yields. Synthesized compounds (4a–z) were screened for in vitro α-glucosidase inhibitory and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activities. Majority of ...