DNA-catalyzed polymerization

X Li, ZYJ Zhan, R Knipe, DG Lynn

文献索引：Li, Xiaoyu; Zhan, Zheng-Yun J.; Knipe, Rachel; Lynn, David G. Journal of the American Chemical Society, 2002 , vol. 124, # 5 p. 746 - 747

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被引用次数: 148

摘要

Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5'- amino-3'-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics to read the encoded sequence and chain-length information in the antiparallel direction. Single mismatches in the template are selected against at a level of> 100: 1. A method is therefore established to translate ...