Synthesis of 1, 3-Diaryl-2-methoxyindenes by Hydriodic Acid–Catalyzed Cyclization of Aryl [2-(1-aryl-2-methoxyvinyl) phenyl] methanols

K Kobayashi, Y Shirai, T Nagaoka…

文献索引：Kobayashi, Kazuhiro; Shirai, Yuu; Nagaoka, Toshiyuki; Konishi, Hisatoshi Synthetic Communications, 2009 , vol. 39, # 16 p. 2866 - 2881

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被引用次数: 7

摘要

Abstract An efficient two-step method for the synthesis of 1, 3-diaryl-2-methoxyindenes from 1-(1-aryl-2-methoxyvinyl)-2-bromobenzenes has been developed. Thus, the reaction of 2-(1- aryl-2-methoxyvinyl) phenyllithiums, generated in situ by halogen–lithium exchange between 1-(1-aryl-2-methoxyvinyl)-2-bromobenzenes and butyllithium, with aromatic aldehydes gives aryl [2-(1-aryl-2-methoxyvinyl) phenyl] methanols, which in turn are ...