Palladium-catalyzed decarboxylative asymmetric allylic alkylation of enol carbonates

BM Trost, J Xu, T Schmidt

文献索引：Trost, Barry M.; Xu, Jiayi; Schmidt, Thomas Journal of the American Chemical Society, 2009 , vol. 131, # 51 p. 18343 - 18357

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被引用次数: 156

摘要

Palladium-catalyzed decarboxylative asymmetric allylic alkylation (DAAA) of allyl enol carbonates as a highly chemo-, regio-, and enantioselective process for the synthesis of ketones bearing either a quaternary or a tertiary α-stereogenic center has been investigated in detail. Chiral ligand L4 was found to be optimal in the DAAA of a broad scope of cyclic and acyclic ketones including simple aliphatic ketones with more than one enolizable ...