Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant†

WC Shieh, J McKenna, JA Sclafani, S Xue…

文献索引：Organic Process Research and Development, , vol. 12, # 6 p. 1146 - 1155

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被引用次数: 10

摘要

... Organic Process Research & Development. ... figure Scheme 3. Synthesis Plan To facilitate the process scale-up, we decided to develop an alternative synthetic ... figure Scheme 6. Fragment B Synthesis As mentioned in the research synthesis of AST487 (Scheme 1), reaction of 12 ...