Efficient and expeditious synthesis of di-and trisubstituted thiazoles in PEG under catalyst-free conditions

D Zhu, J Chen, H Xiao, M Liu, J Ding…

文献索引：Zhu, Dongjian; Chen, Jiuxi; Xiao, Huilong; Liu, Miaochang; Ding, Jinchang; Wu, Huayue Synthetic Communications, 2009 , vol. 39, # 16 p. 2895 - 2906

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被引用次数: 32

摘要

Abstract An efficient and expeditious catalyst-free protocol was developed for the construction of di-and trisubstituted thiazoles from α-haloketones and thioureas/thioamides in PEG. The reaction was carried out at ambient temperature, and the products were obtained in excellent isolated yields (91–98%). Additionally, PEG could be recovered easily and was reused without evident loss in activity.