Differentiation of isomeric acyl carnitines using tandem mass spectrometry

…, C Guenat, DS Millington, DA Maltby, CR Roe

文献索引：Gaskell, Simon, J.; Guenat, Christian; Millington, David S.; Maltby, David A.; Roe, Charles R. Analytical Chemistry, 1986 , vol. 58, # 13 p. 2801 - 2805

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被引用次数: 38

摘要

Tandem mass spectrometry, uslng a four-sector instrument, has been used to distinguish lsomerlc acylcarnltines. Colllslonal activation of MH'ions (or of acykarnltlne methyl ester I cations) Induces fragmentatlons of the acyl moieties, yielding daughter ions wt? h relative abundances characteristic of indhrkluai isomers. Wed analyses of crude urfne samples from children with metaboik disorders enable unequlvocal Identification of Individual ...