Tandem mass spectrometry, uslng a four-sector instrument, has been used to distinguish lsomerlc acylcarnltines. Colllslonal activation of MH'ions (or of acykarnltlne methyl ester I cations) Induces fragmentatlons of the acyl moieties, yielding daughter ions wt? h relative abundances characteristic of indhrkluai isomers. Wed analyses of crude urfne samples from children with metaboik disorders enable unequlvocal Identification of Individual ...
