Synthesis of novel carbazole chalcones as radical scavenger, antimicrobial and cancer chemopreventive agents

…, BA Koti, NA Dhole, RN Gacche, A Shirfule

文献索引：Bandgar, Babasaheb P.; Adsul, Laxman K.; Lonikar, Shrikant V.; Chavan, Hemant V.; Shringare, Sadanand N.; Patil, Sachin A.; Jalde, Shivkumar S.; Koti, Basawaraj A.; Dhole, Nagesh A.; Gacche, Rajesh N.; Shirfule, Amol Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 3 p. 593 - 600

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被引用次数: 10

摘要

A series of novel carbazole chalcones has been synthesised and evaluated for radical scavenging activity, cytotoxicity and antimicrobial activities. Compounds 12m, 12o and 12c exhibited good 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, compounds 12e, 12m and 12d were excellent hydroxyl radical scavengers and compounds 12a, 12e, 12g, 12n and 12m have shown inhibition of oxidative DNA damage induced by ...