Nucleosides and Oligonucleotides with Diynyl Side Chains: Base Pairing and Functionalization of 2′??Deoxyuridine Derivatives by the Copper (I)??Catalyzed Alkyne …
Abstract Oligonucleotides containing the 5-substituted 2′-deoxyuridines 1b or 1d bearing side chains with terminal C [TRIPLE BOND] C bonds are described, and their duplex stability is compared with oligonucleotides containing the 5-alkynyl compounds 1a or 1c with only one nonterminal C [TRIPLE BOND] C bond in the side chain. For this, 5-iodo-2′- deoxyuridine (3) and diynes or alkynes were employed as starting materials in the ...
