Helvetica chimica acta

Nucleosides and Oligonucleotides with Diynyl Side Chains: Base Pairing and Functionalization of 2′??Deoxyuridine Derivatives by the Copper (I)??Catalyzed Alkyne …

F Seela, VR Sirivolu

Index: Seela, Frank; Sirivolu, Venkata Ramana Helvetica Chimica Acta, 2007 , vol. 90, # 3 p. 535 - 552

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Citation Number: 76

Abstract

Abstract Oligonucleotides containing the 5-substituted 2′-deoxyuridines 1b or 1d bearing side chains with terminal C [TRIPLE BOND] C bonds are described, and their duplex stability is compared with oligonucleotides containing the 5-alkynyl compounds 1a or 1c with only one nonterminal C [TRIPLE BOND] C bond in the side chain. For this, 5-iodo-2′- deoxyuridine (3) and diynes or alkynes were employed as starting materials in the ...