Synthesis and activities of a thienyl dihydropyridine series on intracellular calcium in a rat pituitary cell line (GH3/B6)

M Varache-Lembège, A Nuhrich, V Zemb…

文献索引：Varache-Lembege; Nuhrich; Zemb; Devaux; Vacher; Dufy European Journal of Medicinal Chemistry, 1996 , vol. 31, # 7-8 p. 547 - 556

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被引用次数: 12

摘要

The synthesis of a thienyl dihydropyridine series according to the Hantzsch method is described. The influence of these derivatives on intracellular calcium ([Ca+]) in GH3 cells was evaluated in vitro using spectrofluorimetry with indol as Ca+ f fluorescent probe. We compared their effects on [Ca+] i and hormone release with those of nifedipine. The most active tested compounds on [Ca+] i were those methylated on the 3-position of the thienyl ...