Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives

K Nakamoto, I Tsukada, K Tanaka, M Matsukura…

文献索引：Nakamoto, Kazutaka; Tsukada, Itaru; Tanaka, Keigo; Matsukura, Masayuki; Haneda, Toru; Inoue, Satoshi; Murai, Norio; Abe, Shinya; Ueda, Norihiro; Miyazaki, Mamiko; Watanabe, Naoaki; Asada, Makoto; Yoshimatsu, Kentaro; Hata, Katsura Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4624 - 4626

全文：HTML全文

被引用次数: 17

摘要

Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway.