Tetrahedron

Dendroid peptide structural mimetics of ω-conotoxin MVIIA based on a 2 (1H)-quinolinone core

ZX Guo, AN Cammidge, DC Horwell

文献索引：Guo, Zhao-Xia; Cammidge, Andrew N.; Horwell, David C. Tetrahedron, 2000 , vol. 56, # 29 p. 5169 - 5175

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被引用次数: 16

摘要

Three mimetics of the peptide ω-Conotoxin MVIIA have been synthesised following the dendroid approach. The three key central amino acids of the natural peptide are mimicked by phenylguanidine (arginine), isopentyl (leucine) and aryl alcohol (tyrosine) attached to a quinolinone core at the 1-and 8-positions. The derivatives are designed to position these key groups in similar spatial orientation to that of the natural peptide in a structure that will ...