Synthesis and biological activity of acetyl-protected hydroxybenzyl diethyl phosphates (EHBP) as potential chemotherapeutic agents

…, LZ Cieciura, L Pospishill, D Boring, JA Crowell…

文献索引：Kodela, Ravinder; Chattopadhyay, Mitali; Nath, Niharika; Cieciura, Lucyna Z.; Pospishill, Liliya; Boring, Daniel; Crowell, James A.; Kashfi, Khosrow Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 7146 - 7150

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被引用次数: 3

摘要

Several acetyl-protected hydroxybenzyl diethyl phosphates (EHBPs) that are capable of forming quinone methide intermediates were synthesized and their cell growth inhibitory properties were evaluated in four different human cancer cell lines. Compounds 1, 1a, and 1b, corresponding to (4-acetyloxybenzyl diethylphosphate),(3-methyl-4-acetyloxybenzyl diethylphosphate), and (3-chloro-4-acetyloxybenzyl diethylphosphate), were significantly ...