The synthesis of a novel class of antiulcer agents, the substituted 4-phenyl-2-(1-piperazinyl) quinolines, and their pharmacological activities (inhibitory effects on hypothermia induced by reserpine and on gastric ulcers induced by stress or ethanol) are described. These compounds can be classified into three groups (a group predominantly effective on the stress-induced ulcer, one effective on both the stress-and ethanol-induced ulcers, and one ...
