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Reactions of β-Keto Esters with Aromatic Amines. Syntheses of 2-and 4-Hydroxyquinoline Derivatives1

CR Hauser, GA Reynolds

文献索引:Hauser; Reynolds Journal of the American Chemical Society, 1948 , vol. 70, p. 2402

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被引用次数: 103

摘要

We have found that both crotonate and anilide formations are reversible; the crotonate is converted to the anilide by heating with an equivalent of water and a trace of acid4 at 130- 140, whereas the reverse transformation takes place upon boiling the anilide with ethanol and Drierite. Furthermore, in contrast to ethyl acetoacetate, 2-ethylbutyl and n-amyl acetoacetates were found to react with aniline to form mainly the corresponding ...