Tetrahedron letters

Regiochemical observations on the lithiation of 1, 2, 4-trichlorobenzene and reaction with DMF and oxamide electrophiles in THF

…, TW Packham, JC Prodger, MB Schilling, MD Walker

文献索引：Burton, Andrew J.; Cardwell, Kevin S.; Fuchter, Matthew J.; Lindvall, Mika K.; Patel, Rajnikant; Packham, Terry W.; Prodger, Jeremy C.; Schilling, Mark B.; Walker, Matthew D. Tetrahedron Letters, 2003 , vol. 44, # 30 p. 5653 - 5656

全文：HTML全文

被引用次数: 11

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Unusual regiochemistry is observed in the products arising from the reaction of lithiated 1,2,4-trichlorobenzene with N,N-dimethylformamide and tetraalkyloxamides. ... The α-keto amide 3 is a key intermediate in the synthesis of the sodium channel blocker GW356194 4. 1 The synthesis of 3 has ...