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Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase

AA Mortlock, KM Foote, NM Heron…

文献索引:Journal of Medicinal Chemistry, , vol. 50, # 9 p. 2213 - 2224

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被引用次数: 203

摘要

... Journal of Medicinal Chemistry. ... properties and have been demonstrated to possess potent antitumor activity in preclinical models. Chemistry. Compounds 5−39 were prepared as shown in Scheme 1. To explore the ...