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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase

AA Mortlock, KM Foote, NM Heron…

Index: Journal of Medicinal Chemistry, , vol. 50, # 9 p. 2213 - 2224

Full Text: HTML

Citation Number: 203

Abstract

... Journal of Medicinal Chemistry. ... properties and have been demonstrated to possess potent antitumor activity in preclinical models. Chemistry. Compounds 5−39 were prepared as shown in Scheme 1. To explore the ...

 Related Synthetic Route
7-(3-Hydroxypropoxy)-4(1H)-quinazolinone Structure

557770-89-5

7-(3-Hydroxypro...

~%

[5-[7-(3-Chloropropoxy)quinazolin-4-ylamino]pyrazol-3-yl]acetic acid Structure

557770-91-9

[5-[7-(3-Chloro...

7-fluoro quinazolin-4-ol Structure

16499-57-3

7-fluoro quinaz...

~%

[5-[7-(3-Chloropropoxy)quinazolin-4-ylamino]pyrazol-3-yl]acetic acid Structure

557770-91-9

[5-[7-(3-Chloro...

2-(5-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide Structure

722544-46-9

2-(5-{[7-(3-chl...

~%

AZD-1152 Structure

957881-03-7

AZD-1152

1H-pyrazole-3-acetic acid, 5-amino- Structure

174891-10-2

1H-pyrazole-3-a...

~%

AZD-1152 Structure

957881-03-7

AZD-1152

Barasertib (AZD1152-HQPA) Structure

722544-51-6

Barasertib (AZD...

~%

AZD-1152 Structure

957881-03-7

AZD-1152

di-tert-butyl 2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl phosphate Structure

722544-50-5

di-tert-butyl 2...

~%

AZD-1152 Structure

957881-03-7

AZD-1152

7-(3-Hydroxypropoxy)-4(1H)-quinazolinone Structure

557770-89-5

7-(3-Hydroxypro...

~%

AZD-1152 Structure

957881-03-7

AZD-1152

7-(3-CHLOROPROPOXY)-4-CHLOROQUINAZOLINE Structure

557770-90-8

7-(3-CHLOROPROP...

~%

AZD-1152 Structure

957881-03-7

AZD-1152

[5-[7-(3-Chloropropoxy)quinazolin-4-ylamino]pyrazol-3-yl]acetic acid Structure

557770-91-9

[5-[7-(3-Chloro...

~%

AZD-1152 Structure

957881-03-7

AZD-1152

7-fluoro quinazolin-4-ol Structure

16499-57-3

7-fluoro quinaz...

~%

AZD-1152 Structure

957881-03-7

AZD-1152

1H-pyrazole-3-acetic acid, 5-amino- Structure

174891-10-2

1H-pyrazole-3-a...

~%

Barasertib (AZD1152-HQPA) Structure

722544-51-6

Barasertib (AZD...

7-(3-Hydroxypropoxy)-4(1H)-quinazolinone Structure

557770-89-5

7-(3-Hydroxypro...

~%

Barasertib (AZD1152-HQPA) Structure

722544-51-6

Barasertib (AZD...

7-(3-CHLOROPROPOXY)-4-CHLOROQUINAZOLINE Structure

557770-90-8

7-(3-CHLOROPROP...

~%

Barasertib (AZD1152-HQPA) Structure

722544-51-6

Barasertib (AZD...

[5-[7-(3-Chloropropoxy)quinazolin-4-ylamino]pyrazol-3-yl]acetic acid Structure

557770-91-9

[5-[7-(3-Chloro...

~%

Barasertib (AZD1152-HQPA) Structure

722544-51-6

Barasertib (AZD...

7-fluoro quinazolin-4-ol Structure

16499-57-3

7-fluoro quinaz...

~%

Barasertib (AZD1152-HQPA) Structure

722544-51-6

Barasertib (AZD...

7-fluoro quinazolin-4-ol Structure

16499-57-3

7-fluoro quinaz...

~%

7-(3-CHLOROPROPOXY)-4-CHLOROQUINAZOLINE Structure

557770-90-8

7-(3-CHLOROPROP...

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Detail Synthetic Route


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