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Multi??Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C

…, PS Jackson, DS Brown, IR Baxendale…

文献索引：Storer, R. Ian; Takemoto, Toshiyasu; Jackson, Philip S.; Brown, Dearg S.; Baxendale, Ian R.; Ley, Steven V. Chemistry - A European Journal, 2004 , vol. 10, # 10 p. 2529 - 2547

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被引用次数: 92

摘要

Abstract The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.

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