Total synthesis of epothilone A: the macrolactonization approach

KC Nicolaou, F Sarabia, S Ninkovic…

文献索引：Yang; He; Vourloumis; Vallberg; Nicolau Angewandte Chemie - International Edition in English, 1997 , vol. 36, # 1-2 p. 166 - 168

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被引用次数: 135

摘要

The novel molecular structures of the epothilones, for example epothilone A (1, Figure I), coupled with their antifungal"'21 and antitumor activities ['41 and microtubule binding properties [41 promise an exciting new chapter in chemistry, biology, and medicine. Particularly intriguing is the ability of these compounds to displace taxol from its binding site on microtubules,[41 towards which epothilones exhibit much higher affinity than ta~ ol.[~ l ...