The Journal of organic chemistry

Synthesis of pyrazoles via CuI-mediated electrophilic cyclizations of α, β-alkynic hydrazones

M Zora, A Kivrak

文献索引：Zora, Metin; Kivrak, Arif Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9379 - 9390

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被引用次数: 60

摘要

Synthesis of pyrazoles via electrophilic cyclization of α, β-alkynic hydrazones by copper (I) iodide is described. When treated with copper (I) iodide in the presence of triethylamine in refluxing acetonitrile, α, β-alkynic hydrazones, prepared readily from hydrazines and propargyl aldehydes and ketones, undergo electrophilic cyclization to afford pyrazole derivatives in good to excellent yields. The reaction appears to be general for a variety of ...