Synthesis and Structure-Active Relationship of 1-Aryl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline Anticonvulsants

…, S Agnello, E Russo, G De Sarro, A Chimirri

文献索引：Gitto, Rosaria; De Luca, Laura; Ferro, Stefania; Agnello, Stefano; Russo, Emilio; De Sarro, Giovanbattista; Chimirri, Alba Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 12 p. 1602 - 1605

全文：HTML全文

被引用次数: 3

摘要

We have previously disclosed that some 6, 7-dimethoxyisoquinoline derivatives are able to produce anticonvulsant effects in different animal models of epilepsy. Following these studies this paper describes the synthesis of a small series of new 1-aryl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinolines strictly related to previously reported analogues. This novel series of isoquinolines was designed on the basis of well defined structure–active ...