Synthesis and Structure-Active Relationship of 1-Aryl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline Anticonvulsants

…, S Agnello, E Russo, G De Sarro, A Chimirri

Index: Gitto, Rosaria; De Luca, Laura; Ferro, Stefania; Agnello, Stefano; Russo, Emilio; De Sarro, Giovanbattista; Chimirri, Alba Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 12 p. 1602 - 1605

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Citation Number: 3

Abstract

We have previously disclosed that some 6, 7-dimethoxyisoquinoline derivatives are able to produce anticonvulsant effects in different animal models of epilepsy. Following these studies this paper describes the synthesis of a small series of new 1-aryl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinolines strictly related to previously reported analogues. This novel series of isoquinolines was designed on the basis of well defined structure–active ...