Scaffold??Inspired Enantioselective Synthesis of Biologically Important Spiro [pyrrolidin??3, 2′??oxindoles] with Structural Diversity through Catalytic Isatin??Derived 1, 3?? …
…, ZL Tao, SW Luo, SJ Tu, LZ Gong
文献索引：Shi, Feng; Tao, Zhong-Lin; Luo, Shi-Wei; Tu, Shu-Jiang; Gong, Liu-Zhu Chemistry - A European Journal, 2012 , vol. 18, # 22 p. 6885 - 6894
Abstract Catalytic asymmetric construction of the biologically important spiro [pyrrolidin-3, 2′-oxindole] scaffold with contiguous quaternary stereogenic centers in excellent stereoselectivities (up to> 99: 1 dr, 98% ee) has been established by using an organocatalytic 1, 3-dipolar cycloaddition of isatin-based azomethine ylides. This protocol represents the first example of catalytic asymmetric 1, 3-dipolar cycloadditions involving ...
