Design, synthesis, and evaluation of novel 3, 6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2

…, JW Maxwell, TP McDonald, F Kinose…

文献索引：Wolkenberg, Scott E.; Zhao, Zhijian; Thut, Catherine; Maxwell, Jill W.; McDonald, Terrence P.; Kinose, Fumi; Reilly, Michael; Lindsley, Craig W.; Hartman, George D. Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2351 - 2358

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被引用次数: 12

摘要

Agonists of somatostatin receptor subtype 2 (sst2) have been proposed as therapeutics for the treatment of proliferative diabetic retinopathy and exudative age-related macular degeneration. An HTS screen identified 2-quinolones as weak agonists of sst2, and these were optimized to provide small molecules with sst2 binding and functional potency comparable to peptide agonists. Agonist 21 was shown to inhibit rat growth hormone ...