Design, synthesis, and evaluation of novel 3, 6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2

…, JW Maxwell, TP McDonald, F Kinose…

Index: Wolkenberg, Scott E.; Zhao, Zhijian; Thut, Catherine; Maxwell, Jill W.; McDonald, Terrence P.; Kinose, Fumi; Reilly, Michael; Lindsley, Craig W.; Hartman, George D. Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2351 - 2358

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Citation Number: 12

Abstract

Agonists of somatostatin receptor subtype 2 (sst2) have been proposed as therapeutics for the treatment of proliferative diabetic retinopathy and exudative age-related macular degeneration. An HTS screen identified 2-quinolones as weak agonists of sst2, and these were optimized to provide small molecules with sst2 binding and functional potency comparable to peptide agonists. Agonist 21 was shown to inhibit rat growth hormone ...