Continuous flow synthesis for bioactive natural products is described. Efficient procedures using the microfluidic system were developed for the large-scale synthesis of important synthetic units of asparagine-linked oligosaccharide in glycoprotein. Advantageous aspects of microfluidic conditions, ie, efficient mixing, fast heat transfer, and residence time control led to cation-mediated reactions, such as α-sialylation, β-mannosylation, and reductive ...
