4, 6-Disubstituted 2, 2-dimethylchromans structurally related to the KATP channel opener cromakalim: design, synthesis, and effect on insulin release and vascular …

…, P De Tullio, B Becker, MH Antoine…

文献索引：Sebille, Sophie; De Tullio, Pascal; Becker, Benedicte; Antoine, Marie-Helene; Boverie, Stephane; Pirotte, Bernard; Lebrun, Philippe Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 614 - 621

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被引用次数: 31

摘要

Five series (ureas, thioureas, carbamates, sulfonylureas, and amides) of 4, 6-disubstituted-2, 2-dimethylchromans structurally related to cromakalim were prepared and evaluated, as putative ATP-sensitive potassium channel activators, on rat pancreatic islets and rat aorta rings. The biological data indicate that most compounds were, like the reference molecule cromakalim, more active on the vascular smooth muscle tissue (myorelaxant effect on 30 ...