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Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl) piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl) amide, a high affinity TRPV1 (VR1 …

DM Swanson, AE Dubin, C Shah…

文献索引:Journal of Medicinal Chemistry, , vol. 48, # 6 p. 1857 - 1872

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被引用次数: 181

摘要

... Journal of Medicinal Chemistry. ... effects observed for both TRPV1 agonists and antagonists, TRPV1 receptor ligands represent an important opportunity for the discovery of novel analgesic agents which has attracted the attention of several pharmaceutical companies and ...