Synthetic Communications®

One-Pot wittig and Knoevenagel reactions in ionic liquid as convenient methods for the synthesis of coumarin derivatives

H Valizadeh, S Vaghefi

文献索引：Valizadeh, Hassan; Vaghefi, Sevil Synthetic Communications, 2009 , vol. 39, # 9 p. 1666 - 1678

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被引用次数: 47

摘要

Abstract Efficient synthesis of a variety of 3-substituted coumarins via NaOMe-catalyzed Knoevenagel condensation and one-pot preparation of 3, 4-unsubstituted coumarins in the presence of NaOMe via Wittig reaction in room-temperature ionic liquids are described. Knoevenagel condensation of 2-hydroxybenzaldehyde with dimethyl-and diethylmalonate was performed with excellent yields in room-temperature ionic liquids. Although diethyl- ...