Inhibitory effect of the alkyl side chain of caffeic acid analogues on lipopolysaccharide-induced nitric oxide production in RAW264. 7 macrophages

…, T Imaizumi, S Kanno, M Takeshita, M Ishikawa

文献索引：Uwai, Koji; Osanai, Yuu; Imaizumi, Takuma; Kanno, Syu-ichi; Takeshita, Mitsuhiro; Ishikawa, Masaaki Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 16 p. 7795 - 7803

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被引用次数: 62

摘要

Caffeic acid esters, one of the components of propolis, are known to show a variety of biological effects such as anti-tumor, anti-oxidant, and anti-inflammatory activities. Although, the anti-inflammatory activities of caffeic acid esters have been studied by analyzing their structure, the detailed mechanisms of their activities remain unclear. Thus, in this study, we examined the function of the ester functional group and the alkyl side chain (alcoholic part ...