N-Pyridinyl-indole-3-(alkyl) carboxamides and derivatives as potential systemic and topical inflammation inhibitors

…, MR Nourrisson, J Brelet, J Courant, G LeBaut…

文献索引：Duflos, Muriel; Nourrisson, Marie-Renee; Brelet, Jacques; Courant, Jacqueline; LeBaut, Guillaume; Grimaud, Nicole; Petit, Jean-Yves European Journal of Medicinal Chemistry, 2001 , vol. 36, # 6 p. 545 - 553

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被引用次数: 67

摘要

N-substituted-(indol-3-yl) carboxamides 10–15 and alkanamides 16–18 were prepared starting from the corresponding acids and submitted to screening for evaluation of their anti- inflammatory activity. None of the considered carboxamides exhibited significant inhibitory effect in the carrageenin-induced rat paw oedema after oral administration of 0.1 mMkg− 1; nevertheless introduction of an alkyl chain, leading to alkanamides 16–18, induced ...