N-substituted-(indol-3-yl) carboxamides 10–15 and alkanamides 16–18 were prepared starting from the corresponding acids and submitted to screening for evaluation of their anti- inflammatory activity. None of the considered carboxamides exhibited significant inhibitory effect in the carrageenin-induced rat paw oedema after oral administration of 0.1 mMkg− 1; nevertheless introduction of an alkyl chain, leading to alkanamides 16–18, induced ...
