Tetrahedron: Asymmetry

Chemoenzymatic synthesis of (R)-and (S)-1-heteroarylethanols

MI Toşa, PV Podea, C Paizs, FD Irimie

文献索引：Tosa, Monica Ioana; Podea, Paula Veronica; Paizs, Csaba; Irimie, Florin Dan Tetrahedron Asymmetry, 2008 , vol. 19, # 17 p. 2068 - 2071

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被引用次数: 12

摘要

A chemoenzymatic methodology for the synthesis of highly enantiomerically enriched (S)- and (R)-1-heteroarylethanols by enantioselective bioreduction with baker's yeast of the corresponding 1-heteroarylethanones followed by three racemization free chemical steps including a Mitsunobu reaction was developed.