Synthesis and pharmacology of a series of 3-and 4-(phosphonoalkyl) pyridine-and-piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists

PL Ornstein, JM Schaus, JW Chambers…

文献索引：Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833

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被引用次数: 58

摘要

We recently prepared a series of 3-and 4-(phosphonoalkyl) pyridine-and-piperidine-2- carboxylic acids tu antagonists of neurotransmission at N-methyl-D-aspartate (NMDA) preferring receptors. NMDA antagonists may prove to be useful therapeutic agents, for instance, as anticonvulsants, in the treatment of neurodegenerative disorders such as Alzheimer's disease and in the prevention of neuronal damage that occurs during cerebral ...